Computational Biologist/Bioinformatician

Wellcome Trust Sanger Institute - Computer Science

Fixed term for 3 years.

A highly motivated Bioinformatician is required, to investigate genomic datasets from defined projects carried out by our team. The appointment grade will be commensurate to the successful applicant's expertise.

Our Group studies the pathogenesis and treatment of haematological cancers with an emphasis on myeloid leukaemias. We work towards this through a number of complementary approaches including the analysis of human normal and leukaemia samples, the identification of therapeutic vulnerabilities of leukaemia cells using CRISPR-Cas9 screens and the study of bespoke mouse and cellular models of leukaemia-associated gene mutations. Our overarching aim is to improve the survival and quality of life of patients with leukaemia and related cancers.

This is a new position that has been created to provide both day-to-day support and strategic direction for the bioinformatic needs of our Group. This will involve the exploration of genomic datasets generated by our studies including DNA and methylome sequencing, RNA-seq/splicing, ChIP-Seq, single cell genomics and analysis of CRISPR-Cas9 screens. Working closely with our computational and wet lab scientists, as well as the extended Cancer Programme (http://www.sanger.ac.uk/science/programmes/cancer-genetics-and-genomics), the successful candidate will be responsible for the analysis, integration and visualisation of these datasets and will be able to harness the extensive expertise already available at the Sanger Institute for such analyses. A highly motivated individual will also be given the opportunity to pursue their own independent project in the field of leukaemia and/or related disorders.

Whilst direct expertise in such studies/analyses is desirable, enthusiasm, rigour and intellectual curiosity are more important for this role. It is also envisaged that, as the role develops, the successful candidate will be given the opportunity to supervise visiting bioinformaticians or co-supervise MPhil students from the University of Cambridge or elsewhere.

Essential Skills

  • PhD or equivalent expertise in a relevant subject area (e.g. Computational Biology, Population Genetics/Genomics, Computer Science, Physics, Mathematics or similar)
  • Enthusiasm, intellectual curiosity and rigour
  • Proficiency in one or more scripting languages (e.g. C, C++, Perl, Python, Java)
  • Strong statistical and quantitative skills
  • Ability to manage own projects

Ideal Skills

  • Experience in genomics and sequencing data acquisition methods
  • Good publication record
  • Experience of developing software systems
  • Track record of delivering complex informatics projects
  • Knowledge and experience of UNIX/Linux and cluster computing
  • Experience in presenting data to outside groups or at national/international meetings
  • Experience in supervising others

Other information

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.

Closing date for applications: 9th October 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.

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South East England