Tissue Services Manager

University of Birmingham - College of Medical and Dental Sciences

Fixed term for 4 years

Full time starting salary is normally in the range £29,301 to £38,183. With potential progression once in post to £40,523 a year.

This post will be based in the Human Biomaterials Resource Centre (HBRC) which resides within the Advanced Therapies Facility (ATF) in the College of Medical and Dental Sciences. The HBRC is an HTA licensed, ethically approved human sample biorepository, dedicated to the collection and storage of appropriately consented, quality-assured human biomaterials for distribution to biomedical research groups both in academia and industry. The facility provides sample processing, tissue based histological and analytical services, and hosts valuable sample collections (including samples collected from participants in clinical trials). The role of the HBRC is to facilitate the funding and expedition of high quality clinical research. It is a valuable resource, not only for local scientists, but also for researchers throughout the UK and EU, including the commercial sector. The HBRC is a quality controlled environment regulated by both the MHRA and the HTA.

The main role of the post holder will be to manage and oversee all aspects of the tissue-based processing and analytical services delivered by the HBRC. It will involve handling human tissue samples collected from patients in a wide range of disease settings and/or being analysed as part of clinical trials, and may also encompass work with pre-clinical models (e.g. mouse tumour material and primary human tumour cell lines). There is a particular emphasis on the provision of high quality, fully validated and automated immunohistochemistry, multiplex immunofluorescence, and in situ hybridisation services to enable immune-phenotyping and monitoring of cancer patients with solid tumours and in chronic inflammatory conditions. The post holder will also be expected to contribute to the further development and expansion of the digital image analysis service.

The post-holder must be able to co-ordinate the delivery of these services according to the agreed specifications, time, and budgets, and in a manner compliant with the appropriate regulatory and quality standards. A sound knowledge of the regulations, legislation and governance arrangements applicable to clinical research, experience of handling human tissues and good interpersonal, communication and negotiation skills are essential.

It is envisaged that this post will contribute significantly to the identification and clinical validation of predictive biomarkers which will greatly facilitate the transition of academic studies locally into clinical trials. It will also enable the ATF to greatly expand the core services available by establishing a range of GCP-compliant diagnostic/prognostic and immune-monitoring assays which could be applied to clinical trials. This would be a major attraction to industry.                

To download the details and submit an electronic application online please click on the Apply Online button below; please quote Job Reference in all enquiries. Alternatively information can be obtained from 0121 415 9000 or visit www.birmingham.ac.uk/jobs

Valuing excellence; sustaining investment

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Midlands of England