Advanced Research Assistant - Maternity Cover

Wellcome Trust Sanger Institute - Biological Sciences

We are currently looking for an enthusiastic and technically skilled Advanced Research Assistant to cover maternity leave. The successful candidate will carry out both routine and more bespoke laboratory protocols and procedures.

Our primary research interest involves using animal models to understand rare disease genetics in humans.  We are working on a 5 year project to characterise mouse models of developmental disorders such as intellectual disability and autism, and examine the treatability of these disorders.  The applicant's role will be to provide technical research support for different aspects of this project.  The role spans various molecular and cellular techniques, including human Induced Pluripotent Stem Cell culture, massively parallel reporter assays, CRISPR-A experiments, and chromatin accessibility assays.  There will be varying levels of involvement with molecular and histological characterisation of mouse models of disease, cognitive testing of mice, and cell culture of mutant lines, depending on workload and skills. On the job training will be provided in areas where needed.

The successful candidate will be an excellent communicator to keep both the team and senior staff fully apprised of progress; they will be expected to take a collaborative and pragmatic approach when planning the work schedules in order to prioritise effectively. 

Essential Skills

  • BSc in Genetics/Physiology/Anatomy or equivalent significant experience in a relevant area 
  • Significant understanding of molecular genetics 
  • Understanding and significant previous experience in molecular biology techniques including Cloning, PCR, qPCR, RNA isolation, and library construction 
  • Experience using cell culture techniques
  • Experience with statistical packages, data visualisation tools, and other bioinformatic analysis resources
  • Ability to work independently, and show initiative to resolve issues arising
  • Adaptability to changing priorities & workloads, and willingness to learn new skills
  • Good manual dexterity & attention to detail
  • High level of computer literacy
  • Good communication skills 
  • Team oriented approach 

Ideal Skills

  • Experience in microscopy, tissue dissection, processing, and histology 
  • Recent or Current Home Office Personal License for mouse work 
  • Experience of handling and phenotyping mice 
  • Experience of planning and/or conducting experiments using animal models 
  • Experience of planning and/or conducting mouse behavioural experiments with emphasis on cognitive and/or neurological function
  • Willingness to work with mouse models

Other Information

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

Closing date for applications: 11th October 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.

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South East England