Research Associate

Cardiff University - Division of Cancer and Genetics

School of Medicine

College of Biomedical and Life Sciences

We are seeking a highly talented and motivated scientist to become a member of Dr Andrew Tee’s laboratory team, carrying out research on a clinically relevant project entitled ‘Novel Therapies That Selectively Cure Mammalian Target of Rapamycin (mTOR)-addicted Cancer Cells’ which is funded by Cancer Research Wales.

A key mediator of cell growth in many cancers is through aberrant signal transduction through mammalian target of rapamycin (mTOR). Our laboratory has a long-standing research history on dissecting novel mechanisms of mTOR signalling, autophagy and endoplasmic reticulum (ER) stress and then relating this to cancer progression and therapy.

This research project utilises TSC tumour cell line models to test the effectiveness of novel anti-cancer drugs that could easily be repositioned to treat Tuberous Sclerosis (TS) patients. The project will determine whether drug combinations with nelfinavir could be effective at treating TS patients as well as cancer patients that have tumours displaying aberrant mTOR signalling and ER stress.

Applicants should have a PhD in a related subject (or relevant industrial experience) with specific expertise in mTOR, genetic disease relating to mTOR signalling, autophagy and ER stress.

For informal enquiries, please contact Dr Andrew Tee –

This post is full time (35 hours per week), fixed term until 11th April 2018 and is available from 2nd October 2017.

Please be aware that Cardiff University reserves the right to close this vacancy early should sufficient applications be received

Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds who have the ambition to create a University which seeks to fulfil our social, cultural and economic obligation to Cardiff, Wales, and the world. In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.

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