Analytical MS Technician for Metabolite Identification

Imperial College London - Faculty of Medicine

Division of Computation and Systems Medicine

Campus: South Kensington campus of Imperial College with travel as necessary to the Hammersmith Hospital campus

The Clinical Phenotyping Centre (CPC) at Imperial College London is looking to appoint an experienced and motivated analytical chemist to support efforts in the mass spectrometric based identification of unknown compounds from metabolic profiling datasets. The primary source of unknown metabolites will be data generated in recently funded projects from the Institute for Translational Medicine and Therapeutics (ITMAT).

The post holder will form part of a Metabolite Identification team and conduct spectral assignment using available databases as well as performing extraction using chromatographic techniques and de novo structure elucidation of unknown small molecule metabolites by Mass Spectrometry (MS) and computational resources. With input from other members of the team, they will collate sufficient evidence to conclusively confirm metabolite structures. Furthermore, they will help to implement new strategies to address chemical assignment problems. He/she will support the team in providing technical support, day-to-day co-ordination, running and maintaining the laboratory instruments (reagent preparation, replacing solvents, equipment calibration and maintenance), and will participate in preparation of tissue and biofluid samples for analyses.

The successful candidate should have a BSc or equivalent in Analytical Chemistry or a related field, proven experience in identification of small molecules derived from metabolic profiling experiments, in isolation and structure elucidation of metabolites using MS, NMR, and other relevant analytical methodologies like chromatography. Experience in large scale biological sample handling is desirable.

This post is full time and fixed term for one year in the first instance.

Imperial Expectations guide the behaviour of all our staff.

Should you have any queries please contact: Dr Elena Chekmeneva ( or Dr Verena Horneffer-van der Sluis (

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