Research Technician

University of Exeter - Living Systems Institute

The University of Exeter is the fastest rising, fastest growing University in the UK, we offer you the opportunity to join a Russell Group University ranked within the UK top ten and globally recognised amongst its vast range of Sciences.

This fixed term role (24 months) is based in the Living Systems Institute which is a major new initiative designed to promote interdisciplinary research that transcends the boundaries of mathematics, engineering and the biological, medical and physical sciences. Its mission is to analyse living cells and organisms as integrated systems, with the aim of unravelling how diseases disrupt biological processes at the molecular, cellular and organismal level.

We need a team of talented individuals to support our teaching and research, and in training the next generation of top scientists. Working as part of the Phillips lab you will provide direct support to research activities in The Living Systems Institute.

This Research Technician position fits into the central focus of the group’s research: to understand and control how proteins switch between functional states. We are interested in how molecules move, how that movement underpins functional behaviour and how we can control this to engineer new tools for medicine and biosensing. Our core methodology is hydrogen/deuterium-exchange mass spectrometry (HDX-MS), a powerful method to examine the structure and dynamics of proteins.

The post offers the opportunity to take the lead for recombinant protein production within the lab.

You will be a highly motivated researcher with a strong academic background in a STEM subject and an interest in protein structure, dynamics and folding. We are looking for a highly motivated scientist to design, clone, express and affinity-purify naturally-occurring and novel proteins in E.coli. Using expertise within the group, these will be analysed to determine their structure, dynamics and stability. You will then work to explore and optimise the switch-like properties of the proteins, such as by rational design of protein mutants or by library-based screening (e.g. phage display).

Applicants must be:

  • Educated to degree level or possess an equivalent qualification/experience in a related field of study or equivalent experience and be able to demonstrate sufficient knowledge in the discipline and of research methods and techniques to work within established research programmes.
  • Have excellent communication and interpersonal skills to facilitate collaborative work.
  • Knowledge of E. colimolecular biology techniques, protein expression and affinity purification (e.g. His-tag) are essential, as is a strong sense of initiative and self-motivation. Full training in all of the protein characterisation techniques and continued support will be given to ensure that the selected applicant is successful.

For further information please contact Dr Jonathan Phillips, e-mail J.Phillips4@exeter.ac.uk or telephone +44 (0)1392 727456.

We offer a wide range of benefits which can be found here http://www.exeter.ac.uk/staff/benefits/benefits/, and include, generous holiday entitlement, pension, on-site gym and continuous investment in your personal and professional development (see http://www.exeter.ac.uk/departments/technicalservices/).

The University of Exeter is an equal opportunity employer. We are officially recognised as a Disability Confident employer and an Athena Swan accredited institution. Whilst all applicants will be judged on merit alone, we particularly welcome applications from groups currently underrepresented in the workforce

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South West England