Postdoctoral Training Fellow

Institute of Cancer Research - Functional Genomics Team

A Postdoctoral Training Fellow position is available to drive forward high-level research on the generation and functional evaluation of drivers of oestrogen receptive positive (ER+) breast cancer models. The majority of the projects will focus on developing ER+ breast cancer models and further address invasiveness and metastatic disease within this context.

You will be involved in the design and implementation of research projects developing novel therapies for ER+ breast cancer including genetic manipulation of current and novel models to address the drivers of the disease.

Applicants must have a degree in Biochemistry, Molecular Biology or Cell Biology and PhD in molecular or cancer cell biology. Extensive experience in molecular biology and cell biology including generation 3-D cell culture and assay methodologies, CRISPR genome editing as well as experience of in vitro or in vivo screens is essential. Experience and/or ability to learn in vivo models of breast cancer, xenografting and transplantation techniques is also essential.

The post will be based in the Functional Genomics group, under the supervision of Dr Rachael Natrajan. The post-holder will closely interact with other researchers within the group as well as scientists in other ICR Research Groups.

The Functional Genomics laboratory headed by Dr. Rachael Natrajan focuses on understanding the interplay of genetics and microenvironmental changes in the progression of different forms of breast cancer to identify novel drivers and therapeutic targets of the disease. We have made novel advances into the understanding of genomic alterations and their impact on breast cancer in different contexts and how to target these effectively (including Natrajan et al J Pathol 2014; Maguire et al 2014; Bajrami et al Cancer Res 2014; Natrajan et al PLOS Medicine 2015, Maguire et al 2016).

The appointment will be on a Fixed Term Contract for three years. The full salary scale is in the range from £30,410 to £43,463 per annum inclusive. Starting salary will be based on postdoctoral experience.

There is also available a Higher Scientific Officer (HSO) research technician position to provide technical support to an in vivo breast cancer modelling programme in the BCN Research Centre, working in a new breast cancer intraductal MIND modeling team supervised by Dr Beatrice Howard (Breast Development). For further details please go to vacancy reference number 192 following the link below (or copy and paste the link in your internet browser):

Informal enquiries can be made via email to Dr Rachael Natrajan (  Please note – this address is for enquiries only and you should not send your application to this email address.

Please include the following with your application:

  • A full CV with a publication list (two to three pages)
  • Covering letter including the names and contact details of two referees (one page)
  • A one-page summary detailing how the candidate fulfills each of the criteria in the job specification below
  • Research plan (one to two pages outlining your current research interests and research plans for the next 2-3 years)
  • PDF copies of your best 3 publications over the past 5 years

Interviews are likely to take place at the end of October 2017.


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