Postdoctoral Training Fellow

The Francis Crick Institute

Contract: Fixed-term (4 years), Full time

Summary

We seek a talented and motivated postdoc to join Dr Richard Treisman’s Signalling and Transcription laboratory.

Work in the Signalling and Transcription group focusses on the transcriptional targets of Rho and Ras signalling, two major signalling pathways involved in oncogenic transformation, invasion and metastasis. Our main interests are (i) the transcription factor SRF and its control by cofactors, and (ii) the targets and biological roles of the Rho-actin signalling pathway. We use a multidisciplinary approach, involving biochemistry, structural biology, cell biology and genomics, applied to both tissue culture and mouse cancer and immune models.

Details of research projects currently being undertaken can be seen at: https://www.crick.ac.uk/research/a-z-researchers/researchers-t-u/richard-treisman/

Project Scope

RPEL Proteins and the SRF Network in Cell Regulation

The SRF transcription factor is controlled by Ras-ERK and Rho-actin signalling via competing families of pathway-specific regulatory cofactors. The Myocardin-Related Transcription Factors (MRTF-A and MRTF-B) are controlled by Rho-actin signalling, while the Ternary Complex Factors (TCFs: SAP-1, Elk-1 and Net) are Ets-domain proteins controlled by Ras-ERK signalling. MRTF-SRF target genes control many aspects of the cytoskeleton, and balance between MRTF and TCF is an important determinant of fibroblast contractility and invasiveness.

The Rho-actin pathway allows the coordination of protein activity with the dynamics of the actin cytoskeleton. Its effectors, which include the MRTFs, are RPEL proteins, which bind G-actin via the 22-residue RPEL motif. G-actin competes for binding with RPEL protein effectors and regulators, and signal-induced fluctuations in G-actin level therefore modulate RPEL protein activity.

Projects are available in both these areas. Bright experienced, skillful, and adventurous postdocs are sought to develop them.

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

The closing date for applications is Tuesday 17th October 2017 at 23:30 pm.

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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London