Project Research Scientist

The Francis Crick Institute

A talented PhD level molecular biologist is required for an exciting project to analyse outlier cell behaviours in response to EGFR inhibition in lung cancer models. This position is based at the Francis Crick Institute in the Imperial College Photonics Satellite group and Erik Sahai’s group, with close links with AstraZeneca in Cambridge. 

Most pre-clinical drug development work focuses on the mean response of cell populations to interventions and overlooks the small number of cells that do not exhibit this behaviour. The aim of this project is to understand better the relationship between ‘outlier’ cells that respond in an unusual way to EGFR inhibition in the short-term and the emergence of clinical resistance over many months. This research aims to reduce rates of therapy failure and improve patient lives. The project will involve extensive microscopy analysis of fluorescence reporters, including fluorescence lifetime imaging of biosensors, in lung cancer cells treated with third generation EGFR inhibitors. Variance and dynamic changes in signalling downstream of EGFR in the first 48 hours after drug treatment in vitro will be correlated with long term emergence of EGFRi resistance in long-term models and patients. Further molecular analysis to characterize and modulate outlying cell phenotypes will be performed. 

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

The closing date for applications is Monday 23rd October 2017 at 23:30 pm. 

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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