Postdoctoral Researcher

Kingston University - Faculty of Science, Engineering and Computing

The characterisation and quantification of components in novel redox systems using 1D, 2D and Pureshift NMR. This PDRA post is funded by GlaxoSmithKline and builds on the work already undertaken by the Le Gresley group in the field of 2D qualitative NMR analysis and Diffusion characterisation of specific biologically active compounds in saliva/dentifrice slurries.

This project will focus on using a variety of analytical techniques to evaluate redox systems and their products with applications in the Consumer Healthcare field. Technical Summary This project is based on understanding how functional materials can be best formulated in an applied environment for consumer healthcare products. Key functional components found in consumer products contain materials that can be found in reduced and oxidised forms. This project aims to understand not just how these active components exist in solution, but specifically to characterise and evaluate the mechanisms for their interaction. The main goals of this project are to consider two related reactions;

1. A sulphur based redox system.

  • Investigate redox kinetics of the system.
  • Isolate, quantify and characterise any intermediates/products that are formed.
  • Evaluate the reaction of intermediates or products with oxidising species and follow reaction using NMR techniques including DOSY NMR.

2. Reduction of a cationic species.

  • Optimise reduction of an organic cation and characterise the oxygen sensitive product using NMR techniques.
  • Investigate and evaluate varying reaction conditions to increase yield of said product.

The Person
This project would suit a recent PhD graduate with a strong background in organic chemistry and NMR. A sound attention to detail and the ability to carry out statistical analysis (e.g. ANOVA) is important. The successful applicant will be required to undertake extensive 1D/2D NMR analysis of a variety of formulations/reactions and understand the mechanisms and kinetics of the reactions in question. A strong interest in high resolution NMR techniques for complex mixture analysis e.g. DOSY and Pureshift will be needed, but in-house training and support will be provided. They will support the academic lead and help manage the P/G researchers in the Organic chemistry research lab. Good communication skills are essential and experience working as part of a multidisciplinary team would be desirable.

The Faculty
Bringing together teaching and research expertise in science, engineering, computing and mathematics, we provide unique interdisciplinary opportunities. We offer career-focussed courses taught in modern facilities, in everything from automotive engineering to biotechnology, and from maths and games technology to pharmacy.

Further Information
Clicking on the apply button below will take you to Kingston University's website where you will be able to download a job description and apply online. Kingston University is committed to equality and we value the diversity of our staff and students.

The agreed salary for this position is £36,859.

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