Senior Bioinformatician - Cancer and Ageing

Wellcome Trust Sanger Institute - Computer Science

Highly motivated Bioinformatician required to develop State of the Art analysis Tools and Services.

An exciting Software Analysis and Development opportunity has become available to further develop our bioinformatics software stack to help in our goal of understanding human cancer and ageing. The position will be based in the IT Team in the Cancer, Ageing and Somatic Mutation (CASM) Division at the Wellcome Trust Sanger Institute.

The role involves working closely with scientific/IT staff within CASM to develop novel analysis strategies and software. The analysis software needs to be efficient, visually appealing and interpretable by the scientific/clinical community.

This position would suit a Bioinformatician/Software Developer who enjoys developing software tools for the analysis of large genomic data sets. We are looking for an individual who enjoys working in a multi-disciplinary team environment to help solve complex IT issues which will ultimately aid our understanding of mutational processes in humans.

Essential Skills 

  • Good degree in the areas of Bioinformatics, Mathematics, Physics or Computer Science with a scientific background.
  • Software development skills (e.g. Perl and/or Python)
  • Experience of statistical analysis in bioinformatics (e.g. R and/or Julia)
  • Experience of handling Next Generation sequencing data
  • Enjoy working as part of a team

Ideal Skills

  • Software development using a compiled language (e.g. C,C++,Java)
  • LSF or Open Grid scheduling software
  • Experience of OpenStack, VMware or Amazon Web Services (AWS)
  • Experience of working in an Agile Software Development Group
  • ORACLE/MySQL/NoSQL databases
  • Web development using Perl, Java, HTML(5), CSS, JavaScript
  • Background in cancer genetics
  • Ability to work independently, organise own workload and meet tight deadlines

Other Information

Although experience of bioinformatics would be a distinct advantage, applications are welcome from enthusiastic and committed graduates or candidates from other fields who wish to pursue a career in bioinformatics whilst carrying out a challenging and rewarding role.

The CASM Support IT team has developed a suite of algorithms to analyse genetic variation in cancer genome data. This includes software to detect tumour genetic variation (e.g. single-base substitutions, structural rearrangements, copy number changes) and the ability to annotate the resulting variants and mine the data for interesting patterns and signatures (

The CASM Division has led the way in the systematic analysis of cancer genomes by using the human genome sequence and high throughput mutation detection techniques to identify somatically acquired sequence variants/mutations and hence identify genes critical in the development of human cancers (

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.

Closing date for applications:22nd October 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.