Postdoctoral Research Fellow

Queen Mary University of London - William Harvey Research Institute

We are recruiting an enthusiastic post-doctoral research fellow to study Agrin signalling in cartilage regeneration (Eldridge et al. Ann Rheum Dis 2016). This project is funded by the Medical Research Council UK (MRC). The project will investigate the composition of the agrin receptor complex and the intracellular signalling mechanism. Conditional inducible agrin transgenics will be generated and tested in models of cartilage regeneration and of arthritis.

The research group/centre

The Musculoskeletal Regenerative Medicine group is led by Professor Dell’Accio. Our group is focused on the understanding of the molecular mechanisms of joint homeostasis, cartilage biology and regeneration. Within the group, there is a wealth of expertise in animal models of cartilage regeneration and osteoarthritis, molecular and cell biology ( The group thrives on a very strong and welcoming team ethos that fosters synergies and mutual support between the individual members.

The Centre offers state of the art laboratories and is in the heart of the City of London. The Centre is integrated in the Rheumatology department at Barts and the London NHS Trust offering unique translational opportunities.

The candidate

It is essential that the candidate has excellent skills in biochemistry (ideally with robust track record in co-immunoprecipitation), molecular and cell biology. Skills in histological, histochemical and immunostainings are desirable. Knowledge in the fields of skeletal biology, osteoarthritis and developmental biology of the appendicular skeleton as well as chemokine signalling are desirable.

The candidate will be primarily based at the William Harvey Research Institute, Charterhouse Square, London but may also have to travel to The Netherlands for short periods. Some of the work will take place at the Francis Crick institute, London, UK.

Candidates should have a PhD or should be likely to get it within 6 months. The candidate should have good with a good track record of publishing in the field, interpersonal and communication skills, and is an enthusiastic team player.

The post is full time and on a fixed term 36 month contract. Benefits include 30 days annual leave, defined benefit pension scheme and interest-free season ticket loan.

Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.

Informal enquiries about this position can be made to Prof Francesco Dell’Accio by email at

Details about the William Harvey Research Institute, can be found on To apply and for a full job details including a job description and person specification please visit and search for reference QMUL12723.

Application enquiries can be directed to

The closing date for the applications is 25 October 2017. Interviews are expected to take place shortly afterwards.

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