Postdoctoral Research Associate in BBSRC-funded project “Ligase-Free Synthetic Gene Assembly”

Durham University - Department of Chemistry

Full Time & Fixed Term (24 months)

Closing Date: 27 October 2017 (Midday)

 “Ligase-Free Synthetic Gene Assembly” is a BBSRC-funded synthetic biology research collaboration between Dr David Hodgson and Dr Gary Sharples in Durham University, and Dr Heidi Korhonen in the University of Turku, Finland.  The programme targets the delivery of new chemical methods for ligation of nucleic acids, based on the controlled use of reactive species, informed by physical organic chemistry studies. The project has a large synthetic organic component that focuses on the preparation of nucleoside systems. There will also be a requirement to engage with basic biochemical methods. Your research will produce a new method for ligation and synthetic gene assembly that will be tested in model gene systems.

Within the project you will:

  • Perform challenging organic synthetic work towards nucleoside and phosphoramidite systems.
  • Develop in vitro and in vivo ligation assays.
  • Work alongside leading academic and student researchers as part of the project team.
  • Experience broader aspects of synthetic, physical-organic and biological research and collaborative activities within the research team.
  • Receive in-depth training in the scientific aspects of your work as well as key transferable skills.
  • Have the opportunity to publish results in internationally leading journals and to present your work at national and international conferences.

This post is a 24 month PDRA position working on synthetic biology.

The successful applicant will be responsible for all day-to-day aspects of the project. You will work in the Department of Chemistry in Durham and report to Dr David Hodgson. You will work in collaboration with Dr Sharples, PDRAs and PhD students in Durham, and Dr Korhonen in Turku, who will be carrying out oligonucleotide synthesis.

Successful applicants will, ideally, be in place as soon as possible after 1st November 2017.

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Northern England