Research Associate in Cell and Developmental Biology

University of Sheffield - Department of Biomedical Science

Fixed-term for 36 months from 1st January 2018 or as soon as possible thereafter

A Wellcome Trust-funded Postdoctoral Research Associate position is available in the lab of Dr. Matt Towers that aims to understand how cells measure time during vertebrate limb development. We have recently shown that intrinsic timing mechanisms are involved in chick wing development. these intrinsic timers determine the duration of the important signalling molecule sonic hedgehog (Chinnaiya et al, Nat Comms 2014) and specify the pattern of skeletal elements (Saiz-lopez et al, nat comms 2015; Saiz-lopez et al, development 2017). Using a combination of advanced grafting techniques in chick embryos and RNA sequencing we aim to understand if single limb bud cells have the ability to measure time in vivo and if their intrinsic developmental programmes can be re-set and re-executed.

The successful applicant will have a PhD in developmental biology (or equivalent experience) with experience of tissue grafting techniques and gene manipulation in chick embryos. Experience in RNA sequencing and bioinformatics is desirable. The successful candidate will be expected to have excellent interpersonal and communication skills, be highly independent, and committed to research in a fast-moving and competitive field.

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Northern England