Research Associate, Advanced In Vivo Functional Imaging

Imperial College London - Medicine, Brain Sciences

Campus: Hammersmith (White City from 2019)

The UK Dementia Research Institute (UK DRI) at Imperial is seeking an outstanding post-doctoral researcher to take on a challenging role with considerable scope for independent scientific achievement. The post-holder will be a key member of the research staff in the group of the Institute Associate Director, Professor Paul Matthews.

The UK DRI at Imperial has been established to address a medical research area of highest importance and future impact, as one of six new national centres of excellence embedded in major UK universities that together, are intended to transform the diagnosis, treatment and care of people with dementias. MRC and charity partners Alzheimer's Society and Alzheimer’s Research UK have invested £250m in fulfilment of the ambition identified in the Prime Minister's 2020 Challenge on Dementia.

The focus will be on developing and applying advanced in vivo brain imaging methods for characterisation of the dynamics of neuronal activity and function in preclinical neurodegeneration models.  The effort will combine structural and functional MRI and electrophysiological methods to define earliest network level changes in brain function with progression of pathological processes related to Alzheimer’s disease. The impacts of bioelectronic and targeted molecular interventions will be explored. These results will be obtained in a framework to enable their correlation with molecular and cellular changes characterised with novel non-invasive sampling methods or post mortem. The latter will be enabled through expertise in the team or in collaborating groups, relating changes found in human neuropathological samples with those in relevant in vitro cell and, through collaboration with colleagues, preclinical in vivo models. An explicitly translational focus will be maintained.

The successful candidate will help define specific research programmes within this remit and undertake them in conjunction with colleagues in multi-disciplinary teams. Considerable independence will be expected, with anticipation for a growing role in leadership of the research. In addition, he/she will be expected to submit publications to refereed journals and to join in attracting external research funding.

There will be opportunities for supervision of students. Experiences in other teaching roles, including lecturing, will be enabled as part of the broad range of development opportunities that Imperial College makes available to its staff.

The contract is fixed term to 31 August 2022.

For informal inquiries or questions about the role, please contact Professor Paul Matthews directly at

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Should you have any queries about applying for this role, please contact:

Michelle Buckman:

Committed to equality and valuing diversity, we are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see

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