Postdoctoral Research Associate

University of Sheffield - Oncology & Metabolism

Contract Type: Fixed-term for 3 years with an intended start date of 1 November 2017.

Faculty: Faculty of Medicine, Dentistry & Health

Summary

We are seeking a highly motivated Postdoctoral Research Associate to work on DNA replication in eukaryotic cells. Using the papillomavirus system we want to understand how DNA replication is initiated and regulated in the cell cycle. The group is headed by Dr Cyril Sanders (https://www.sheffield.ac.uk/oncology-metabolism/staff/sanders) and we are located in the Department of Oncology & Metabolism which is part of the Sheffield Institute for Nucleic Acids Research (SInFoNiA). The group has strong national collaborations with structural biologists.

You will have a keen interest in structural and molecular biology. We will assemble, purify and characterise discrete protein-DNA complexes that distort, melt and then unwind the DNA double helix. Structures of replication complexes will be determined using cryo electron microscopy (cryo-EM) by our collaborators at Birkbeck College London, where funding is in place for a second postdoctoral position linked to this project. The opportunities offered by the “resolution revolution” in cryo-EM make this is an exciting time to be involved in mechanistic biochemistry.

You should be ambitious, have a PhD in a relevant field and a proven track record of scientific accomplishments. Experience with recombinant protein expression and purification and the analysis of protein-protein and/or protein-DNA interactions are essential, although outstanding candidates with other relevant skills will be considered.

This full-time post is funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and is available from November 2017 for a period of 3 years.

We’re one of the best not-for-profit organisations to work for in the UK. The University’s Total Reward Package includes a competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and development courses to support your personal and professional development.

We build teams of people from different heritages and lifestyles whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.

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Northern England