Postdoctoral Research Assistant

Birkbeck, University of London - Biological Sciences

Purpose and Main Duties

To carry out structural research using cryo electron microscopy of complexes formed by two viral proteins, E1 and E2 and a specific dsDNA sequence to understand replication initiation. Cryo-EM and single-particle analysis (SPA) allow visualisation of particles in solution under near-native conditions. The specific objectives are to determine the structure of the E1E2-ori pre-initiation complex and reveal the ATP-dependent conformational changes in the protein and DNA; to derive a high-resolution cryo-EM structure of the E1 helicase bound to a replication fork junction (RFJ)-like DNA substrate. It is important for both experimental design and interpretation of results to have active scientific interactions with the collaborating laboratories (Dr. C. Sanders, University of Sheffield).

Candidate Requirements

Possess sufficient breadth and depth of specialist knowledge in electron microscopy and of research methods and techniques to work within an established structural biology research programme. Skills in cryo electron microscopy, familiarity with main software packages used in electron microscopy will be desirable.

About the Department

For further information about the Department of Biological Sciences please visit the following website:

Further Information

Salary: Grade 7 of the College's London Pay Scale which is £37,169 rising to £42,483 pro rata per annum.

This post is full time, 35 hours per week (1.0 FTE) and fixed term for up to 36 months. The salary quoted above will be pro-rata for this post and is on the College's London Pay Scale and includes a consolidated Weighting/Allowance which applies only to staff whose normal contractual place of work is in the Greater London area. The initial salary will be dependent on the skills and experience of the successful applicant. The appointment is subject to a probationary period of 12 months. Birkbeck also provides a generous defined benefit pension scheme, 31 days paid leave, flexible working arrangements and other great benefits.

The closing date for completed applications is midnight on 5 November 2017.

Interviews will be held on Monday 20 November 2017.

For further information on this opportunity contact Prof Elena Orlova (

Birkbeck welcomes applicants from all sections of the community. The College is committed to improving the gender and cultural diversity of its workforce, holding an Athena SWAN award and membership of WISE, operating the Disability Confident and Mindful Employer schemes, is a Stonewall Diversity Champion and is working towards the Race Equality Charter Mark.

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