PhD Studentship - Structure and Function of the Accessory Sec System in Gut Symbionts (JUGE_Q18DTP)

University of East Anglia - Biological Sciences

Location: Quadram Institute Bioscience

Start Date: 1st October 2018

No. of positions available: 1

Supervisor: Dr Nathalie Juge

Project description: The human body harbours a diverse and dense population of commensal bacteria, which exerts key functions in terms of nutrition and health. However, the precise mechanisms of how our beneficial intestinal microbes interact with the host remain largely unknown. In this project, you will use a trans-disciplinary approach including structural biology, molecular microbiology, glycobiology and animal models to decipher the pathways dedicated to the secretion of glycosylated adhesins by gut symbionts and their role in colonisation and biofilm formation.

This PhD project will provide mechanistic insights into host-microbe interactions in the gut and help rationally design probiotic-based strategies to promote human health and fight against infection and antimicrobial resistance.

The PhD student will join a dynamic and expanding Group working in the area of gut bacteria-host interaction at Quadram Institute Bioscience and benefit from complementary expertise on X-ray crystallography at the University of East Anglia. The PhD student will receive expert training in bioinformatics, molecular microbiology, structural biology and glycobiology.

This project will benefit from the established network of international collaborations in these research areas. Training will embrace research practice and theory, management, communication (to scientific and lay audiences), intellectual property, teamwork and technical writing. The student will present his/her work to internal seminars and to relevant International meetings. The possible commercial issues relating to the impact of this research on human health will be highlighted and the student will be encouraged to participate into outreach activities.

This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (NRPDTP). Shortlisted applicants will be interviewed as part of the studentship competition. Candidates will be interviewed on either the 9th, 10th or 11th January 2018.

The Norwich Biosciences Doctoral Training Partnership (NRPDTP) offers postgraduates the opportunity to undertake a 4 year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team.

For further information and to apply, please visit our website: www.biodtp.norwichresearchpark.ac.uk

Person specification: Students with, or expecting to attain, at least an upper second class honours degree, or equivalent, are invited to apply.

Funding notes: Full Studentships cover a stipend (RCUK rate: £14,553pa – 2017/8), research costs and tuition fees at UK/EU rate, and are available to UK and EU students who meet the UK residency requirements.

Students from EU countries who do not meet the UK residency requirements may be eligible for a fees-only award. Students in receipt of a fees-only award will be eligible for a maintenance stipend awarded by the NRPDTP Bioscience Doctoral Scholarships, which when combined will equal a full studentship. To be eligible students must meet the EU residency requirements. Details on eligibility for funding on the BBSRC website: www.bbsrc.ac.uk/web/FILES/Guidelines/studentship_eligibility.pdf

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Type / Role:

PhD

Location(s):

South East England