PhD Studentship: Trans-Generational Inheritance of Environmental Information Using Regulation of Long Non-Coding RNA. (PENFIELD_J18DTP1)

University of East Anglia - School of Biological Sciences

Supervisor: Professor Steve Penfield

Project description

Seeds are now understood to be highly plastic in their development and behaviour depending on environmental signals that control their development, particularly temperature. Crucially, temperature signals are not just perceived by seeds themselves but also by the mother plant, and the mother has major influences on seed development. We have shown that the mother plant has a memory of environmental temperature stretching back several weeks that controls reproductive development leading to seed dormancy. This memory is carried by a key gene known as FLOWERING LOCUS C (FLC) which can form epigenetic memories of past temperature experience. This project will investigate the mechanism by which the mother sends temperature information to FLC, using a mechanism involving regulation of non-coding RNAs transcribed at the FLC locus. The work will involve advanced training in plant molecular biology including epigenetics, epigenomics, use of reporter genes and microscopy to examine how temperature information is inherited into seeds. The successful applicant will join a large and well-funded research team with access to state-of-the-art facilities and world-leading expertise in plant reproductive biology.

This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (NRPDTP). Shortlisted applicants will be interviewed as part of the studentship competition. Candidates will be interviewed on either the 9th, 10th or 11th January 2018.

The Norwich Biosciences Doctoral Training Partnership (NRPDTP) offers postgraduates the opportunity to undertake a 4 year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team.

For further information and to apply, please visit our website: www.biodtp.norwichresearchpark.ac.uk

Person specification: Students with, or expecting to attain, at least an upper second class honours degree, or equivalent, are invited to apply.

Funding notes: Full Studentships cover a stipend (RCUK rate: £14,553pa – 2017/8), research costs and tuition fees at UK/EU rate, and are available to UK and EU students who meet the UK residency requirements.

Students from EU countries who do not meet the UK residency requirements may be eligible for a fees-only award. Students in receipt of a fees-only award will be eligible for a maintenance stipend awarded by the NRPDTP Bioscience Doctoral Scholarships, which when combined will equal a full studentship. To be eligible students must meet the EU residency requirements. Details on eligibility for funding on the BBSRC website: www.bbsrc.ac.uk/web/FILES/Guidelines/studentship_eligibility.pdf

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Type / Role:

PhD

Location(s):

South East England