Senior Laboratory Research Scientist

The Francis Crick Institute

Short Introduction/Summary

The High Throughput Screening (HTS) facility is one of the core technology platforms available to all researchers at the Crick and enables them to use screening techniques as part of their research. Activities can include, but are not restricted to, genome-wide RNAi screens, large-scale cell-based screens with collections of well-characterised small molecules or proof-of-concept drug discovery screens and increasingly using Crispr screening technologies.

Project Scope/ Description

The HTS facility has a history or providing researchers with the reagents and infrastructure necessary to undertake genome-wide functional genomic screens using arrayed siRNA reagents across a wide variety of disease relevant biological systems. Working within the facility, the post holder will play a role in continuing to develop a novel arrayed CrispR screening platform for the institute in particular the development of a Crispr-targeted gene over-expression screening platform. In addition this role will be pivotal in providing researchers with assistance in creating biologically relevant and informative cell based assays for genome-wide siRNA screens.  This position requires the ability to plan, organise and conduct such a screen across 78,000 samples while balancing a number of such projects at different levels of development simultaneously.  

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

If you are interested in applying for this role, please apply via our website 

The closing date for applications is 06 November 2017 at 23:30 pm.

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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