Senior Research Associate

University of East Anglia - School of Biological Sciences

Faculty of Science

Population genomics of selection at the haploid gametic stage

The successful candidate will join an ERC funded project investigating the importance of selection on the haploid genotype in male gametes in animals. Any sexually reproducing eukaryote undergoes an alternation between diploid and haploid phases. Very few population genetic studies take both phases into account. Improving our understanding of the importance of selection at the haploid gametic level in predominantly diploid organisms such as flowering plants and metazoans has potentially far-reaching consequences for fundamental evolutionary processes, such as rate of adaptation and mutation-selection balance, as well as for clinical applications including assisted fertilisation techniques. Currently, our project is producing a variety of NGS datasets to address these questions, but we lack adequate theoretical and statistical frameworks in population genetics/genomics for well-founded in-depth analyses. The aim of this project is to develop these theoretical and statistical frameworks through the application of theoretical modelling and simulations, in combination with analyses of current and future datasets, to generate and test general and specific predictions addressing selection at the haploid gametic level.

The recent advances in high-throughput sequencing and computational power make it both relevant and realistic to create accurate simulation-based models to evaluate both, novel theory and abundant empirical data. With such models, the influence of different genetic architectures and forms of selection can be evaluated, as well as different “non-ideal” scenarios such as individual deviations in recombination rates, transmission biases such as meiotic drive, and technical complications such as allele-based bias in sequencing, genome alignment errors, etc.

You will have a minimum of a PhD in Population Genetics, Evolutionary Genomics, Medical Genetics, or Bioinformatics, and be able to fulfil all essential elements of the person specification.   Research experience in population genetics/genomics and bioinformatics is a required pre-requisite, as is proficiency in Python or Perl.

This full time post is available immediately for a fixed term of 12 months (with the possibility of extension).

The University is a Bronze Athena Swan Award holder, currently working towards Silver

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South East England