Research Assistant in Differentiation Therapy in Acute Myeloid Leukaemia

University of Oxford - Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine

Applications are invited for a highly motivated postgraduate Research Assistant in a programme studying Acute Myeloid Leukaemia (AML) (the most common aggressive leukaemia) in adults. The post is funded by an industry grant from Celgene Corporation and available full-time until 31 May 2019 in the first instance, based in the laboratory of Professor Paresh Vyas.

The project will integrate genetic, epigenetic and functional data in samples from AML patients treated with novel targeted drug combinations in a Phase III clinical trial, to discover genetic and epigenetic markers of response and therapy resistance.

Patient AML samples will be characterised using established flow cytometry panels, and genotyped using whole exome sequencing and targeted re-sequencing, next generation sequencing (NGS) methods. Clonal structures will be studied using single cell genotyping techniques established in Professor Vyas’ group. In parallel, FACS-purified leukaemia stem cell populations will be used for assays to study chromatin states and DNA methylation. Crucially, samples are studied over the course of treatment on the clinical trial, and data correlated with clinical outcomes. This work will study genetic and epigenetic determinants of response and resistance to novel drug therapies including hypomethylating agents and a specific inhibitor of mutant isocitrate dehydrogenase.

Applicants must hold a degree (minimum 2:2) in biology, genetics, biochemistry or in a biomedically-related area. You will have experience in tissue culture, basic molecular biology and flow cytometry (FACS). Previous experience of FACS cell sorting, working with Illumina sequencing platforms and competency in basic bioinformatic analysis (e.g. working from command line, ability to use R biostatistical packages) is highly desirable, however training can be offered in these areas. The post requires the ability to work as part of a team. The ability to work independently when appropriate is essential, together with effective communication, interpersonal and organisational skills.

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application

The closing date for this position is 12.00 noon on Friday 10 November 2017. Interviews will be held week commencing 27 November 2017.

Please note that the University of Oxford's retirement policy has changed. With effect from 1 October 2017, all employees at Grade 8 and above have a retirement age of the 30 September before the 69th birthday. All employees at Grades 1-7 do not have a set retirement age. Further details are available here: https://www.ox.ac.uk/about/jobs/preemploymentscreening.

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=131434

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