Postdoctoral Research Associate

King's College London - School of Cancer and Pharmaceutical Sciences

The salary will be paid at Grade 6, £33,518 - £36,613 per annum, plus £2,923 per annum London Allowance.

This post will be for 5 years

This is Full time post – 100% full time equivalent

We have recently discovered that antibody-based chemokine blocking antibodies, that can modulate the tumour infiltration by T lymphocytes and other effector cells of the innate immune system (Cancer research 2017; 77: 1083-1096 and Journal of immunology research 2016: 7803091), can create a measurable effect in the stiffness of the tumour microenvironment by non-invasive imaging methods such as Magnetic Resonance Elastography (MRE). 

We are seeking an interactive and self-motivated immunologist (or biologist who has basic immunological skills) to work on imaging the interaction between the innate/adaptive immune components with the stromal microenvironment of breast/lung cancers in order to validate our imaging results obtained at the macro scale by live cellular resolution imaging using multiphoton intravital microscopy; which will also quantify the collagen content, a biological correlate of the stiffness of the tumour microenvironment which we postulate is impacted on by the immune cell interaction with stromal cells that deposit collagen in the tumour microenvironment.

He/she will image of the relevant cell-cell interactions (and the associated inter-molecular interactions at the interface) in the tumour microenvironment (TME) involving basal-like cancer cells, stromal cells and various immune cells e.g. innate lymphoid cells, dendritic cells, macrophages, T effector cells and regulatory T/B cells, etc as potential biomarkers. Clinical patient samples will be imaged for validation of the preclinical observation. The post holder would be expected to collaborate with physicists and biophysicists from both KCL and UCL particularly the exosomal group within the Richard Dimbleby Research Lab and Comprehensive Cancer Imaging Centre.

The selection process will include competency based questions, a presentation, and a Panel interview

For an informal discussion to find out more about the role please contact Prof. Tony Ng (tony.ng@kcl.ac.uk and http://www.cancerresearchuk.org/our-research/researchers/professor-tony-ng

To apply for this role, please go to the King’s College London HireWire Job Board and register to download and submit the specified application form.

The deadline for applications is midnight on 9 November 2017.

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