Postdoctoral Research Associate in Assembly of repressive heterochromatin by the 'HUSH' complex

University of Cambridge - Cambridge Institute for Medical Research - Medicine

We are seeking an enthusiastic, motivated individual for a Wellcome Trust funded postdoctoral position in the group of Professor Paul Lehner at the Cambridge Institute of Medical Research on the Cambridge Biomedical Campus, University of Cambridge

You will join an exciting research programme using genetic and proteomic approaches to characterise the mechanism of action of the **HUSH epigenetic transcriptional repressor complex (Tchasovnikarova IA et al Science. (2015) 348:1481-5, Nature Genetics (2017) 49:1035-1044)** which deposits the H3K9me3 repressive mark and is responsible for the chromatin-mediated repression of cellular transgenes and newly integrated retroviruses.

This post will involve the use of cutting edge genetic, biochemical, proteomic and bioinformatic techniques to study the mechanism of HUSH-mediated silencing. Candidates must have experience in the chromatin field, in chromatin biochemistry and cell biological techniques. Quantitative and analytical skills, as well as expertise in bioinformatics are also desirable.  If you have an excellent background in biological sciences, have published in high impact journals, are prepared to face intellectual challenges and wish to develop your scientific skills, we would like to hear from you.

Applicants should have excellent organisation and communication skills, and work well as part of a team.

Fixed-term:  Funds for this position are available for 3 years in the first instance with an immediate start date.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy and to view further information about the role, please visit: This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form.

For further details or informal enquires please contact Paul Lehner via email (

Please quote reference SC10695 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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South East England