PhD Studentship in Enabling Next Generation Additive Manufacturing

University of Nottingham - Engineering

Hybrid bioinstructive / delivery particles fabricated through combining surfactant free microfluidic particle manufacture, two photon polymerisation and phase separation”

In collaboration with Warwick and Birmingham Universities, as well as with the School of Pharmacy and Physics at Nottingham, the Centre for Additive Manufacturing (CfAM) http://www.nottingham.ac.uk/research/groups/cfam/index.aspx will continue a deeper exploration the area of multifunctional AM through the recently awarded Programme Grant, Enabling Next Generation Additive Manufacturing.

The programme vision is to establish controlled next generation multifunctional AM and translate this to industry and researchers. Initially focussing on novel electronic and pharmaceutical/healthcare applications, the aim is to move beyond single material AM by exploiting the potential to deposit multiple materials contemporaneously for the delivery of spatially resolved function and structure in three dimensions.

Project description: 

This project is predicated on the principle that cells, such as macrophages, interact with foreign bodies in a three-dimensional way. In addition, it is well known that the condition and morphology of surfaces that the cells come into contact with have a strong influence on the phenotypical/functional direction that the cells embark upon. Therefore, whilst much insight has been obtained from cells on planar surfaces, a true understanding can only be obtained by challenging cells with features of the appropriate length scale, and then tailoring the surface condition to induce specific pathways. We will address this through the combination and advancement of two recent developments – microfluidics for production of particles with highly tuned interfacial properties and two photon polymerisation for topological manufacture and freedom. This will be a significant step forward as this will allow the production of objects that work on two length scales – 1. Production of ‘macroscale’ objects that are particularly relevant to the mechanisms of macrophage behaviour and 2. On nanoscale length scales much smaller than the cell size, on which it has been shown that cells are influenced.

Requirements of the studentship:

  • UK or EU candidates should have, or expect to obtain, a first-class or 2:1 degree in Engineering, Physics or Science related discipline.
  • Please send a copy of your covering letter, CV and academic transcripts to CfAM@nottingham.ac.uk. Please note applications without academic transcripts will not be considered. 
  • Candidates will be available to start on 1st October 2018.
  • Please refer to the project title when sending your e-mail/application.
Share this PhD
     
  Share by Email   Print this job   More sharing options
We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

PhD

Location(s):

Midlands of England