Postdoctoral Research Assistant in Nucleic Acid Ligand Binding

University of Reading - Pharmacy

Working on a collaborative BBSRC grant between Pharmacy and Chemistry at the University of Reading, and Prof. Sorenson at Diamond Light Source, you will be involved in understanding the fundamental science behind metal complex binding to nucleic acid structures. The project involves the synthesis of established and novel metal complex to probe the structural features and specificity of binding to a range of nucleic acid targets, including duplexes, with or without areas of damage, quadruplexes, and RNA structures.

We are looking for a motivated scientist for 2 years (in the first instance, possibly extending to 3 years depending on progress of the project), who has an interest in working at the interface between synthetic chemistry, biophysical characterization, and x-ray crystallography.

You will have:

  • Expertise in synthetic chemistry, ideally in both organic and coordination chemistry, for the preparation of metal complexes.
  • Experience of biophysical techniques including UV, CD, and fluorescence spectroscopy.
  • PhD in Chemistry/Pharmacy or related subject, or be within 3 months of submission.
  • Knowledge of nucleic acid structure and ideally macromolecular crystallography.
  • Computer skills at a level to undertake crystal structure determination.
  • An ability to work methodically and within a larger team.
  • A willingness to travel.

The University is committed to having a diverse and inclusive workforce, is a Stonewall Diversity and Global Diversity Champion, and supports the principles of the Race Equality Charter and Athena SWAN. Applications for job-share, part-time, and flexible working arrangements are welcomed and will be considered in line with business needs.

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South East England