Research Fellow in Behavioural Epigenetics

University of Leeds - School of Biology

Are you an ambitious researcher looking for your next challenge? Do you have an established background in Behavioural/Evolutionary biology, including next-generation sequencing analysis, and an interest in epigenetics? Do you want to further your career in one of the UKs leading research intensive Universities?

We are seeking a highly motivated bioinformatics-based research fellow to investigate the role of the epigenetic reprogramming in co-ordinating behavioural responses to fine-scale environmental fluctuations. This project addresses a fundamental gap in our knowledge of how environmental change affects animal behaviour. Drosophila melanogaster males respond to cues of sperm competition from their social environment by changing their mating behaviour. In this project we have used chemical inhibitors and RNAi to establish which epigenetic modifications mediate this sperm competition response. We are currently performing ChIP-seq to determine which genes are affected.

Your main responsibility will be to analyse ChIP-seq data, use existing datasets to put these into a wider context and take a lead role in writing arising papers, you may also be involved in molecular and/or behavioural assays to verify these data. The work is in collaboration with a PDRA mainly working on the wet lab assays, and it is hoped that you will work closely to support each other’s activities and share skills. This Leverhulme Trust funded project is based in Dr Amanda Bretman’s research group at the University of Leeds and in collaboration with Dr Elizabeth Duncan. 

You will have a PhD (or close to completion) in animal behaviour, molecular genetics, epigenetics, bioinformatics or a closely allied discipline, experience in analysing next-generation sequencing data using command line/Linux based programs, and a background in using molecular techniques.

Interviews will take place in the week commencing 8 January 2018.

To explore the post further or for any queries you may have, please contact: 

Dr Amanda Bretman, Lecturer in Animal Biology

Tel: +44 (0)113 343 7214, email: a.j.bretman@leeds.ac.uk

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Northern England