Research Fellow in Chemical Biology/Medicinal Chemistry

University of Sussex - School of Life Sciences

We wish to appoint a Research Fellow in Chemical Biology/Medicinal Chemistry, which carries on from work published in ACS Chem. Biol., 2016, 11, 2265,  on rescuing wild-type p53 in Y220C mutant cancers. Around 100,000 cases of this tyrosine to cysteine mutation are found annually and these lead to thermal instability of the protein via the creation of a druggable cavity into which our molecules can fit and effectively stabilise the protein, preventing unfolding and rescuing apoptosis.

The project involves the synthesis of libraries of mainly small drug-like molecules for biological evaluation and x-ray structural studies by our collaborators (Prof. Sir Alan Fersht FRS, Cambridge, and Dr Andreas Joerger, DKTK, Frankfurt). 

Candidates with a PhD in medicinal chemistry or chemical biology are encouraged to apply. For further details on the Spencer group, see The laboratories are equipped with state of the art parallel synthesis, microwave, automatic purification and evaporation, LC-MS and analytical equipment.

The University of Sussex values the diversity of its staff and students and we welcome applicants from all backgrounds

The School is committed to equality and valuing diversity, and currently holds an Athena SWAN Silver Award. Applications are particularly welcomed from women and black and minority ethnic candidates, who are under-represented in academic posts in Science, Technology, Engineering, Medicine and Mathematics (STEMM) at Sussex. The School of Life Sciences welcomes applications to academic posts from candidates who wish to work part-time or as job-sharers.

The University offers various schemes to provide real benefits to parents, these can be found at Family Friendly Policies

Potential candidates are strongly encouraged to make informal contact with the Subject Chair for Chemistry or the Head of the School of Life Sciences (Professor Sarah Guthrie), before applying.

Applications should be accompanied by a full CV, a statement of research interests and aspirations (not more than 4 pages), and the names of three academic referees. [Optional

For full details and how to apply see our vacancies page.

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South East England