Scientific Researcher – Neurobiology

MRC Laboratory of Molecular Biology

The MRC Laboratory of Molecular Biology is a world leader in biological research, with an expanding scientific programme dedicated to understanding gene function in health and disease. It provides an unsurpassed environment for both young and established researchers. Scientists are drawn to the LMB from all over the world, creating a lively and international community for the exchange of ideas and technical innovation.

We are looking for a Scientific Researcher to join Dr Anne Bertolotti’s pioneering research programme on serine/threonine phosphatases. The Bertolotti lab discovered a selective way to inhibit phosphatases which consists in targeting their regulatory subunits. This is important because phosphatases were thought to be undruggable before this work (see Tsaytler et al., 2011, Science, 332, 91-4; and Das et al., 2015, Science, 348, 239-242, Carrara, Sigurdardottir and Bertolotti. Carrara, M., Sigurdardottir, A., & Bertolotti, A. (2017). Nat Struct Mol Biol, 24(9), 708–716).

You will join a strong inter-disciplinary team at the LMB which has broad expertise extending from biochemistry, x-ray crystallography, chemical biology, molecular and cell biology through to transgenic animal models of degenerative diseases.  We also have an excellent record of innovative basic research leading to applications in medicine.

You will make a significant contribution to a project aimed at capitalizing on our pioneering discoveries on phosphatases. The project consists in further developing biochemical assays to quantitatively measure phosphatase activity and inhibition with recombinant proteins and characterize phosphatase function and activity. Further information about the position may be obtained from Dr Anne Bertolotti– email: aberto@mrc-lmb.cam.ac.uk.

You will be ambitious, creative and fearless. You will have a PhD in biochemistry/biophysics/crystallography or due to complete doctoral studies within 6 months of applying. Relevant experience is required and this must be best attested by at least one impactful publication. Experience with biochemistry and/or biophysics is essential. Experience with recombinant protein production is essential. Experience with assay development is an advantage. Experience working with difficult proteins is an advantage. Experience with SPR, MST is an advantage.

You will enjoy interacting with a dynamic interdisciplinary team sharing a passion for science and a commitment to explore the unknown. The successful candidate will be awarded an 11-month Scientific Researcher contract.

Your salary is supported by 30 days’ annual leave entitlement pro rata, an optional MRC final salary pension scheme and excellent on site sports and social facilities.

For further information on the LMB, please visit: http://www2.mrc-lmb.cam.ac.uk. To apply and access full details of the vacancy please visit our job board at https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/776. If you are unable to apply online please contact us at hradmin@mrc-lmb.cam.ac.uk.

Closing date: 2nd January 2018

This position is subject to a pre employment screening. The Medical Research Council is an Equal Opportunities Employer

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South East England