Research Associate (British Lung Foundation Research Scientist)

Cardiff University - Division of Cancer & Genetics

We seek to appoint a talented and driven postdoctoral immunologist to the Tissue MicroEnvironment Group, based at the School of Medicine, Cardiff University.  The successful candidate will be working on the British Lung Foundation funded project, ‘Combination treatment modelling for personalised immunotherapy in mesothelioma’, led by Dr Zsuzsanna Tabi, Head of the Cancer Immunology Unit.

The aim of the laboratory-based work is to establish an ex-vivo explant model studying how the tumour microenvironment influences the behaviour of autologous immune cells, with a special emphasis on CD8+ T cell activity. Checkpoint inhibitors alone or in combination with other treatments will be applied, with the aim of overriding immunosuppression. The data will be evaluated in connection with a complete genetic and immunological profiling of the tumour, using NanoString® technology, at individual patient level. The prognostic value of tumour signature will be analysed from patient samples obtained from a clinical trial employing checkpoint inhibitors in mesothelioma. Successful completion of the study will influence future treatment planning and patient stratification for immunotherapy in mesothelioma.

The successful applicant is expected to have a knowledge of cancer immunology and extensive laboratory experience with T cell assays, flow cytometry and cytokine arrays. Ex-vivo tissue microscopy expertise would be an advantage but high-level training will be provided on various imaging platforms, including non-linear 2-photon laser scanning microscopy geared for live cell tissue slices.

The project requires an individual who is self-motivated, able to work within a multidisciplinary team and has excellent written and oral communication skills.

For informal enquiries, please contact Dr Zsuzsanna Tabi - TabiZ@Cardiff.ac.uk.

This post is full-time (35 hours per week), and available from 2nd January 2018. The position is fixed term for one year, as part of a three year research project.  The duration of the position will be reviewed as part of the project and there is a possibility it may (or not) be extended for a further 18 months.

Salary: £32,548 - £38,833 per annum (Grade 6)

Date advert posted: Friday, 24 November 2017

Closing date: Tuesday, 2 January 2018

Please be aware that Cardiff University reserves the right to close this vacancy early should sufficient applications be received.

Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds who have the ambition to create a University which seeks to fulfil our social, cultural and economic obligation to Cardiff, Wales, and the world. In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.

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