Higher Scientific Officer - Molecular and Cell Biology

Institute of Cancer Research - Cancer Therapeutics

The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.
A Higher Scientific Officer position is now available in the Hit Discovery and Structural Design Team within the Unit. The team combines small-molecule high throughput screening, assay development and High-Throughput Screening with fragment-based hit discovery, biophysical assays and X-ray crystallography. The successful candidate will use molecular and cell biology to develop cell-based assays for the screening of compound libraries and the profiling of cellular activities of inhibitors for a key cancer target in collaboration with the Cancer Biomarkers Team led by Prof. Johann de Bono. The post-holder is expected to apply detailed technical knowledge to develop, execute and analyse novel cell-based luciferase reporter assays for this target. The successful candidate will be an integral member of a multidisciplinary project team and will interact closely with the biologists, computational chemists, medicinal chemists, structural biologists and clinician-scientists.

Applicants must have a degree in Biochemistry, Molecular Biology or Cell biology and good technical laboratory experience in mammalian cell culture, molecular and cell biology methodologies is essential. Knowledge of reporter assays and drug discovery would be desirable.

Appointment will be to a Higher Scientific Officer with starting salary in the range of £32,628 to £33,961 p.a. inclusive (and the post is offered on a fixed term contract of 1 year in the first instance and benefits from a contributory defined benefit pension scheme and generous leave entitlement Informal enquiries to rosemary.burke@icr.ac.uk or rob.vanmontfort@icr.ac.uk

We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.
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South East England