Research Associate

University of Sheffield - Chemistry

Contract Type: Fixed term for 12 months

Faculty: Faculty of Science

Location: Dainton Building


Applications are invited for a research associate to work with Professor Nick Williams in the Department of Chemistry at the University of Sheffield to work on an EPSRC programme to develop artificial transmembrane signalling systems. You will join a multidisciplinary team of based in Sheffield focussed on physical organic chemistry, using organic synthesis, inorganic complexes, supramolecular systems and biological chemistry.

The aim is to develop molecular systems which are capable of transmitting chemical information across a lipid membrane in a similar manner to coupled membrane protein receptors. Transduction of a chemical signal from the outside of a vesicle is to be achieved via controlled translocation which will trigger a chemical process on the inside of the vesicle. Relatively simple building blocks will be used so that a range of different strategies can be explored. You will work as part of a larger team in collaboration with the research group of Professor Chris Hunter (University of Cambridge). The role will involve organic synthesis of catalytic complexes associated with membrane embedded molecules; studies of the kinetic properties of these systems; incorporation into vesicles; assessment of recognition triggered transmembrane signalling properties. The Cambridge group will explore different chemical recognition processes that can control the activity of the catalyst on the inside of the vesicles.

Applicants should have (or be about to obtain) a PhD in chemistry or have equivalent experience. Experience in some or all of organic synthesis, physical organic chemistry and kinetic analysis is required. You will be expected to give verbal presentations on your work, write internal reports and produce draft publications. In addition to your own research, you will be expected to take some responsibility for the supervision and training of post-graduate and undergraduate research students and for the day-to-day running of the laboratory.

We’re one of the best not-for-profit organisations to work for in the UK. The University’s Total Reward Package includes a competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and development courses to support your personal and professional development.

We build teams of people from different heritages and lifestyles whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.

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Northern England