Research Associate

University of Cambridge - Department of Oncology

We are seeking to appoint two Research Associates to investigate in the cell of origin of cancer. These posts will be based in the laboratory of Dr Daniel Munoz-Espin, who is a Group Leader in the Department of Oncology at the University of Cambridge. These are new posts funded by the Medical Research Council (MRC).

One of the main goals of the Dr Munoz-Espin's research programme is the understanding of the mechanisms and processes that contribute to the origin of cancer at the cellular level, which remains a formidable challenge in oncology. We are looking for researchers to work at the interface between cellular plasticity, senescence, cancer stem cells and cancer, with a focus on (but not restricted to) lung tumours. Candidates must have a PhD (or equivalent) in the biological or biomedical sciences, and relevant experience working in cancer fundamental research, cellular biology and lineage tracing. Skills in cellular reprogramming and culture of stem and iPS cells is desirable but not essential. Candidates must have at least one first-author research article accepted for publication in a major peer-reviewed journal. International experience and/or interconnections with the research industry would be desirable.

The successful applicants will perform experiments with cancer, lineage tracing and reprogrammable models, and also will have active access to human tissue samples in collaboration with the Papworth Hospital Research Tissue Bank and the Human Research Tissue Bank of the Cambridge Biomedical Research Centre. Our final aim is to isolate and characterise tumour initiating cells, to test the contribution of associated processes, and to identify the underlying mechanisms. Translation of this knowledge is crucial to develop more efficient methods for cancer diagnosis and to implement more efficient therapeutic interventions.

The laboratory of Dr Munoz-Espin is part of the Early Detection Programme of the Cancer Research UK Cambridge Centre, (http://www.earlydetectioncambridge.org.uk/), which is core funded by Cancer Research UK (http://www.cancerresearchuk.org/), the largest independent cancer research organisation in the world.

Informal enquiries are welcomed, and should be directed to Dr Munoz-Espin at dm742@cam.ac.uk.

Fixed-term: The funds for this post are available for 2 years in the first instance, with the possibility of a 3rd year.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

To apply online for this vacancy and to view further information about the role, please visit:

http://www.jobs.cam.ac.uk/job/15964.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Closing date for applications is the 7th January 2018, with interview likely to take place week commencing the 22nd January 2018.

Please quote reference RD14193 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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