Senior Research Associate

University of East Anglia - School of Biological Sciences

Faculty of Science

Why do we age: linking evolutionary causes with proximate mechanisms 

We are seeking highly motivated and enthusiastic postdoctoral Senior Research Associate for ERC-funded project on the evolution of ageing in the Maklakov lab in the School of Biological Sciences at University of East Anglia.

Understanding ageing is one of the big unsolved problems in biology. Recent progress in the study of ageing has challenged the current paradigm that ageing results from energy trade-offs between survival and reproduction. In this project, we will work at the interface of evolutionary biology and bio-gerontology towards the goal of explaining the mismatch between this paradigm and the empirical findings. We will focus on i) uncovering potentially missing parts of the classic survival/reproduction trade-off; and ii) testing an emerging new theory of ageing that aims to replace the classic view. In practical terms, we will use the whole range of interventions that increase longevity and postpone senescence – e.g. diet, pharmaceuticals that mimic dietary effects, mutations and RNAi knockdowns of genes in nutrient-sensing signalling networks in Caenorhabditis nematodes – to link molecular signalling pathways to physiological processes to transgenerational effects on Darwinian fitness.

The ultimate goal here to advance our understanding of the ultimate causes of ageing while making the “black box” of the mechanisms underpinning life-history evolution more transparent.

The Senior Research Associate will help setting up the new lab, conduct experimental work using Caenorhabditis nematodes as the model organism, help supervising and training new lab members and actively participate in the research life of the lab and the School, such as seminars and journal clubs. Funding is available for further training and professional development by attending national and international conferences and workshops.

You will be expected to have a PhD in Biology (or working towards) or equivalent qualification, publications in peer-reviewed journals in related fields such as evolutionary biology, biomedicine or biogerontology and be able to fulfil all essential elements of the person specification.

This full time post is available for a fixed term period from 1 March 2018 until 28 February 2021.

The University is a Bronze Athena Swan Award holder, currently working towards Silver.

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South East England