PhD Studentship - How do Diets Rich in Broccoli Prevent Prostate Cancer Progression? (MITHEN_Q18BCS)

University of East Anglia - School of Biological Sciences

Location: Norwich (Quadram Institute Bioscience)

Start Date: 1October 2018

No. of positions available: 1

Supervisor: Prof Richard Mithen

Project description: Intake of cruciferous vegetables such as broccoli is negatively correlated with incidence of prostate cancer. On the Norwich Research Park cultivars of broccoli have been developed that accumulate enhanced levels of sulphur-containing compounds with potential anti-cancer activity, and are being used in clinical intervention trials with men who have organ-confined prostate cancer. This studentship, based in the Quadram Institute, will explore how these plant metabolites affect gene expression and metabolism in the prostate cancer tumour

microenvironment to inhibit the growth of cancerous clones. The research will involve the use of cell and ex vivo human tissues models and a short term human intervention study in collaboration with clinicians at the Norfolk and Norwich University Hospital. The appointee will acquire a range of skills in molecular biology and biochemistry and work closely with clinical colleagues. The research will lead to further development of functional food products that may be helpful in reducing prostate cancer progression. For further details please contact:

richard.mithen@quadram.ac.uk

For further information and to apply, please visit our website: quadram.ac.uk/about/student-opportunities

Person specification: UK equivalent 2:1. Please see more information on entry requirements here: www.uea.ac.uk/study/postgraduate/research-degrees/how-to-apply/entry-requirements

Funding notes: This project is awarded with a 4 year Norfolk Cancer Charity BIG C PhD studentship. A stipend will be provided for each year of the studentship (2017/8 rate is £14,553.00). Tuition fees are covered for UK/EU rate. International students are eligible for funding but will need to find their own support to cover the extra tuition fees chargeable to overseas students. (Tuition fee rates for 2017/8 for UK/EU students is £4,195.00, for international students it is £18,000.00). Research training support funding is available in a well-funded laboratory.

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Type / Role:

PhD

Location(s):

South East England