Postdoctoral Training Fellow (Tumour Heterogeneity and Drug Resistance)

Institute of Cancer Research

A position for a Postdoctoral Training Fellow is available within the multidisciplinary Protein Networks Laboratory (led by Dr. Paul Huang) in The Institute of Cancer Research based in Chelsea. This project is funded by Cancer Research UK through a Career Establishment Award to Dr Huang. The project will be to study sub-clonal interactions and tumour heterogeneity driving EGFR inhibitor resistance in lung cancer. 

We are looking for a motivated and enthusiastic scientist to characterise clonal drug resistant subpopulations in lung cancer cell lines using deep profiling approaches (phosphoproteomics/proteomics and NGS) Molecular profiles will be integrated with targeted synthetic lethal and drug screen data to identify kinase pathway dependencies in lung cancer.

Applicants will hold a PhD in Biology, Biochemistry, Molecular Biology, or a similar discipline. The successful candidate will be experienced in generating, analyzing and integrating proteomic, phosphoproteomic (mass spectrometry) and NGS data.

Applicants must have experience in standard cell biology techniques and will be expected to undertake extensive tissue culture of clonal cell lines. Hands-on experience in generating and analyzing functional screen data including CRISPR, RNAi or drug screens is desirable. A proficiency in clonal lineage tracing with barcoding technology will be useful. Knowledge in signal transduction, lung cancer, tumour heterogeneity and cancer evolution would be advantageous.

Candidates will be capable of working independently, be ambitious and driven to achieve goals and are expected to have at least one first author peer reviewed publication at the time of application.   

The appointment is fixed term until January 2020. The full salary scale for this post is in the range from £30,410 to £43,463 p.a. inclusive. Starting salary will be based on previous postdoctoral experience. 

Informal enquiries can be made to Dr. Paul Huang (paul.huang@icr.ac.uk). Please do not send your application to Dr Paul Huang, formal applications must be submitted online. 

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