Postdoctoral Training Fellow in Bioinformatics/Computational Biology

The Francis Crick Institute

Short Introduction/Summary

We are seeking a highly motivated Bioinformatics/Computational biology Scientist to join Prof Dominique Bonnet’s laboratory. The lab works on the regulation of human normal haematopoietic stem cell biology and leukemia and the role of the extracellular factors providing by the niche.

Details of research projects currently being undertaken in HSCL lab can be seen at:

We seek a talented, productive and motivated postdoc with a desire to work in a congenial, dynamic and collaborative research team. The post holder will be part of the team of researchers working in the Haematopoietic Stem Cell laboratory under the direction of Prof Dominique Bonnet.

Project Scope/ Description

The group is interested in studying normal human Haematopoietic Stem Cells (HSCs) and Leukaemic Stem Cells (LSCs). At present we are investigating the relationship between normal HSCs, LSCs and their microenvironment. For this we are using NSG, RNA seq, Single cell analysis as well as Chip-Seq/ATAC-seq, proteomics and are thus looking at integrating these multi-omics data to generate new hypotheses that can be functionally tested using our in vivo patient derived xenotransplantation models.

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

The closing date for applications is 03 January 2018 at 23:30.

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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