Postdoctoral Training Fellow

The Francis Crick Institute

Contract: Fixed-term (4 years), Full time

Short Introduction/Summary

A post-doctoral position is being available in the “Human normal and malignant hematopoietic stem cells and their microenvironment to study the role of human normal and leukemic stem cells” headed by Prof.Dominique Bonnet. The laboratory is interesting in studying human normal haematopoietic stem cells (HSCs) and leukaemic stem cells (LSCs). We are at present investigating the relationship between normal HSC, LSC and their microenvironment. For that we have developed in vivo imaging techniques allowing us to visualise and define the normal and leukaemic stem cells niche in vivo. We have also developed 3D scaffold system where human stroma cells could be co-cultured in vivo with HSC or LSC to study the effect of the interaction and study the cross-talk between stroma and HSC/LSC. All these projects should shed light into pathways or interactions that are more specifically used by LSC and where therapeutic intervention might be developed.

Project Scope/ Description

The successful candidate should have in-depth knowledge and experience in relevant areas of stem cells (more specifically HSC) and /or leukemia in order to develop a project focused on understanding how leukemic cells impede on normal HSC. Candidates must have expertise in a wide range of stem cell biology and molecular techniques, including primary stem cell isolation/characterization/culture, flow cytometry and cell sorting. Experience in leukaemia is desirable. The post-holder will be expected to engage in the research activities of the team, write up results in the form of reports and publications, and present research outcomes at project meetings and national and international meeting.

Details of research projects currently being undertaken in HSCL lab can be seen at:

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

The closing date for applications is 03 January 2017 at 23:30.

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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