Research Associate in Single-Molecule Optical Microscopy for Nanopore Sensing

King's College London

A postdoctoral researcher is sought for a BBSRC funded project to develop new single-molecule optical tools for nanopore sequencing and sensing in collaboration with Oxford Nanopore Technologies. This post will build on our recent success in optical Single Channel Recording (Huang Nat. Nano. 2015) and interferometric imaging of lipid nanodomains (de Wit PNAS 2015) to improve the sensitivity and speed of optical-based nanopore sensing. By using an optical rather than electrical detection of ionic flux through a protein nanopore we circumvent the ‘one pore per bilayer’ requirements of conventional nanopore sensing. 

This opens a route to high speed nanopore measurements via parallelization. Here we construct a new single-molecule microscope optimised for the task. Candidates with experience in microscope development, instrument construction, image analysis, artificial lipid bilayers, MATLAB programming, and in vitro biochemistry and biophysics are encouraged to apply.

The salary will be paid at Grade 6, £33518 - £39992 per annum, with a discretionary range to £43,685 per annum, plus £2,923 per annum London Allowance.

The selection process will include competency based questions, a presentation, an assessment and a panel interview.

If you have questions about this role, please contact: Mark Wallace, Email: mark.wallace@kcl.ac.uk

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