PhD Studentship - Spectrally-Encoded Endoscopy

University of Birmingham - School of Chemical Engineering

Competition Funded PhD Project (Students Worldwide)

Application Deadline: Applications accepted all year round

Supervisor: A.K. Yetisen

Project Description

Endoscopy enables minimally-invasive diagnostic imaging to reduce the risk of complications, recovery times, and hospitalization costs. The early endoscope designs featured a bundle of optical fibers. Modern endoscopes still consist of bundles of optical fibers to transmit 2D images; their larger models employ solid-state CCD cameras for high-resolution imaging. Fiber-bundle endos-copes having submillimeter diameters are not widely adopted due to their rigidity and low image quality. They have low numbers of pixels and superimposed a honeycomb pattern as pixilation artefacts.

This project aims to develop a disposable, highly-flexible hydrogel optical fiber based endoscope that will offer high-resolution imaging with minimised tissue damage. A spectrally-encoded endoscopy (SEE) system will be utilised to deliver broadband light through the hydrogel optical fiber and the backscattered light will be collected and analysed by a line-scan camera. A hydrogel optical fiber will be fabricated and a diffraction grating will be incorporated at its tip. The hydrogel fiber endoscope will be tested in a living mouse tumor model to optimise the resolution and compare the performance with a commercial solid-state optical fiber endoscope.

The successful student will form part of a multidisciplinary team and will be supervised by Dr. Ali K. Yetisen based in the Institute of Translational Medicine (www.itmbirmingham.co.uk) and the School of Chemical Engineering at the University of Birmingham.

Funding Notes

Students must have an undergraduate degree or master’s degree in engineering, chemistry, physics, materials science or a closely related subject.

University of Birmingham scholarships are available for exceptional UK/EU students. Self-funded international students are welcome to apply this post. Potential candidates should contact Dr. Ali K. Yetisen (a.k.yetisen@bham.ac.uk) and include a CV. Applications will be evaluated on an on-going basis until the position is filled.

References

Glucose-Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid. Advanced Materials. 2017, 29, 1606380 (2017)

Functionalized Flexible Soft Polymer Optical Fibers for Laser Photomedicine. Advanced Optical Materials (2018)

Highly Stretchable, Strain Sensing Hydrogel Optical Fibers. Advanced Materials. 28 (46), 10244-10249 (2016)

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Type / Role:

PhD

Location(s):

Midlands of England