PhD Studentship - Paper-Based Microfluidic Devices

University of Birmingham - School of Chemical Engineering

Competition Funded PhD Project (Students Worldwide)

Application Deadline: Applications accepted all year round

Supervisor: A.K. Yetisen

Project Description

The analysis of tear constituents at point-of-care settings has a potential for early diagnosis of ocular disorders such as eye diseases, low-cost screening, and surveillance of at-risk subjects. However, current minimally-invasive rapid tear analysis systems for point-of-care settings have been limited to the assessment of osmolarity or inflammatory markers and they cannot differentiate between dry eye subclassifications.

The aim of this project is to demonstrate a portable microfluidic system that allows quantitative analysis of biomarkers in the tear fluid that is suited for point-of-care settings. The microfluidic system will consist of a capillary tube for sample collection, a reservoir for sample dilution, and a paper-based microfluidic device for electrolyte analysis. The sensing regions will be functionalised with fluorescent crown ethers, o-acetanisidide, and seminaphtorhodafluor that are sensitive to mono- and divalent electrolytes, and their fluorescence emissions will be measured with a smartphone camera readout device.

The successful student will form part of a multidisciplinary team and will be supervised by Dr. Ali K. Yetisen based in the Institute of Translational Medicine (www.itmbirmingham.co.uk) and the School of Chemical Engineering at the University of Birmingham.

Funding Notes

Students must have an undergraduate degree or master’s degree in engineering, chemistry, physics, materials science or a closely related subject.

University of Birmingham scholarships are available for exceptional UK/EU students. Self-funded international students are welcome to apply this post. Potential candidates should contact Dr. Ali K. Yetisen (a.k.yetisen@bham.ac.uk) and include a CV. Applications will be evaluated on an on-going basis until the position is filled.

References

Paper-Based Microfluidic System for Tear Electrolyte Analysis. Lab on a Chip. 17, 1137-1148 (2017)

Paper-Based Microfluidic Point-of-Care Diagnostic Devices. Lab on a Chip, 13 (12), 2210-2251 (2013)

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Type / Role:

PhD

Location(s):

Midlands of England