Senior Staff Scientist (Computational)

Wellcome Trust Sanger Institute

We are looking for an enthusiastic and skilled Senior Staff Scientist to join the Soranzo team at the Wellcome Trust Sanger Institute ( The post will suit an ambitious and talented individual who is interested in applying his/her skills at the interface of human disease and regulatory genomics.

The Soranzo team at the Sanger Institute studies genomic predisposition to cardiometabolic risk. In the last ten years, we have led international efforts to discover genetic variants associated with both established and emerging risk factors in cardiovascular disease, diabetes and immunity. Distinguishing features of our research are the focus on large-scale science, the use of genome sequencing for genomic exploration, and a focus on high-dimensional ('omic') phenotypes, including metabolomics and gene expression phenotypes.

This position will be primarily responsible for supporting the computational needs of the team, and for the processing, storage and visualisation of large-scale biological datasets. This will include the development of computational tools, databases and web-based interfaces for the analysis, retrieval and visualisation of genetic association datasets in the context of deep phenotypes and functional genomic data. Depending on skills and interests, the candidate will also have the opportunity to be involved in the scientific projects, and primarily in phenotype-genotype analyses of large-scale genomic datasets based on next generation sequencing or molecular phenotypes (gene expression, promoter capture, histone modifications, methylation and transcription factor data). These efforts will inform efforts to characterise the impact of sequence variation through large-scale functional genomic explorations. The post-holder is expected to work in a highly independent manner, and to support the generation of high-impact publications.

This researcher will be embedded an interdisciplinary team of computational scientists, bioinformaticians, statisticians and wet lab scientists seeking to study the functional impact of rare human sequence variation in complex traits and disease.

Essential Skills

  •  A PhD in computer science, computational biology, biostatistics, bioinformatics, or similar numerical discipline
  •  Demonstrated programming skills in shell scripting (e.g. bash, tcsh)
  •  Demonstrated programming skills in an object-oriented language (C, C++, PERL, Python or similar)
  •  Good experience of design and use of relational databases, including MySQL, SQL and Oracle
  •  Experience of visualizing and reporting data, on and off the web
  •  Good communication skills directly with scientific researchers regarding programming and analysis requirements
  •  Documented experience in data parsing, cleansing, data modelling, analysis, and database design and implementation
  •  Excellent communication, organisational and problem-solving skills
  •  Ability to work to tight timelines, both independently and as part of a team
  •  Ability to communicate efficiently with a diverse array of scientific expertise
  •  Enthusiasm, commitment and attention to detail
  •  The ability to anticipate needs and problems while creating solutions

Other Information

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious diseases.

The Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.

Closing date for applications: Friday 2nd February 2018