Postdoctoral Research Associate in innate immune restriction of HIV-1 and related viruses

King's College London - Department of Infectious Diseases

The salary will be paid at Grade 6, £33,518 to £34,520 per annum, plus £2,923 per annum London Allowance.

This post will be a Fixed Term Contract until 31 December 2022 in the first instance

Accumulating evidence suggests that interferon-induced cellular factors that directly block the replication of HIV-1 and related primate lentiviruses play key role in the pathogenesis of HIV/AIDS. In particular, the transmitted viruses display a higher resistance to the antiviral activity of type 1 interferons than viruses isolated during chronic disease. We have shown that one determinant of this is the intrinsic resistance of the viral envelope glycoprotein of transmitted viruses to the interferon-induced membrane protein (IFITM) family that block viral entry into target cells (Foster et al, 2016, Cell Host and Microbe 20(4):429-442. doi: 10.1016/j.chom.2016.08.006).

A full time, Wellcome Trust funded postdoctoral associate position is available from January 2018 in Professor Stuart Neil’s laboratory. This project will entail understanding the molecular and cellular bases for interferon/IFITM resistance in the HIV-1 envelope glycoprotein, how this affects viral tropism and escape from adaptive immune responses, and the potential relevance of these observations to HIV-1 vaccine design. The successful candidate will have a PhD in virology or other relevant molecular biomedical science; previous experience with HIV-1 and innate antiviral restriction is an advantage. They will be hardworking with a proven scientific track record, preferably at least one first author primary research paper in a respected academic journal, and a particular interest in tackling fundamental questions regarding the mechanisms of viral replication. We will actively support postdoctoral fellowship applications to outside funding organisations.

The selection process will include  a presentation and a panel interview.

For an informal discussion to find out more about the role please contact stuart.neil@kcl.ac.uk

To apply for this role, please go to the King’s College London HireWire Job Board and register to download and submit the specified application form.

The deadline for applications is midnight on 28 January 2018

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