Research Fellow in Structural Cell Biology

University of Leeds - Faculty of Biological Sciences

Are you looking to apply your skills in Imaging and Cell Biology to gain a new molecular understanding of how amyloid aggregates disrupt cells and to help develop new routes to combat amyloid diseases?

We are looking for an outstanding postdoctoral research fellow to join a Wellcome Trust-funded team that will investigate how proteins aggregate into amyloid fibrils and how aggregates kill cells. Ultimately the team will involve four post-doctoral researchers and will combine chemical biology, biochemistry, biophysics, structural biology, cell biology, and experiments in C. elegans to define the mechanisms underlying amyloid aggregates to form and the consequences for cells of aggregation. The successful applicant for this post will use imaging methods including cryo-electron tomography and super-resolution light microscopy, combined with cell biology experiments and use of C. elegans models of disease to define the mechanisms of amyloid aggregation in cells and in vivo and to elucidate the effects of treatment with newly discovered small molecules in a cellular context. 

You will be based in the laboratories of Professor Sheena Radford and Professor Neil Ranson, and work closely with our collaborators Drs Eric Hewitt and Patricija van Oosten-Hawle, and other members of the amyloid team. You will have a PhD (or be close to completion) in Cell Biology, Biochemistry, Structural Biology or a related discipline. You will have extensive experience of using imaging methods and cell biology to elucidate biological mechanisms. Experience in cryo-electron microscopy/tomography would be a significant advantage, but training will be given to outstanding candidates lacking this experience.

Further information about the project and recent publications are available within the additional information document.

To explore the post further or for any queries you may have, please contact:

Professor Sheena E Radford, Astbury Professor of Biophysics

Tel: +44 (0)113 343 3170, email: s.e.radford@leeds.ac.uk 

Professor Neil A Ranson, Professor of Structural Molecular Biology

Tel: +44 (0)113 343 7065, email: n.a.ranson@leeds.ac.uk

Location: Leeds - Main Campus

School/Institute: School of Molecular & Cellular Biology / Astbury Centre for Structural Molecular Biology

Working Time: 100%

Contract Type: Fixed Term (for up to 5 years - due to funding)

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