Lead Bioinformatician

Imperial College London - Department of Medicine

Full-time, fixed-term until 31 March 2022

Campus: Hammersmith Campus

Applications are invited for a skilled and motivated PhD level bioinformatician to lead Bioinformatics service and research activities in the NIHR Imperial BRC Genomics Facility.

The NIHR Imperial BRC Genomics Facility provides state-of-the-art laboratory and computational support for translational research in Imperial College London. Its primary goal is to harness genomics information to advance disease diagnostics, prognosis and treatment. It is responsible for the management and processing of NGS data and carries out bioinformatics analysis of large-scale genomic data sets. It develops and maintains computational workflows for NGS data processing and analysis utilising cutting edge bioinformatics tools and high-performance computing resources. It has recently acquired an Illumina HiSeq4000, a NextSeq, and a 10X Genomics Single Cell Chromium.

The post is funded by the Imperial Biomedical Research Centre (BRC) to support the use of bioinformatics strategies to investigate the genetic basis of common and rare human diseases. The successful applicant will lead bioinformatics support activities within the Facility and work with scientists and clinicians from groups across the Faculty of Medicine and the BRC Genomics Facility to analyse large-scale genomic datasets predominantly obtained by NGS based approaches such as whole-genome and exome re-sequencing, RNA-seq and ChIP-seq. The post holder will also carry out the analysis of next-generation sequencing data and supervise the work of junior bioinformaticians in the Facility. Activities will include quality control and mapping of NGS data for variant detection, transcription profiling or epigenetic modification detection; integration of genomic datasets with public and commercial biomedical data sources for annotation and interpretation; development, maintenance and optimisation of analysis pipelines and procedures. The ability to make strategic contributions to experimental design and assist clinicians and scientists with data interpretation are key requirements of the post. Furthermore, the post holder will be encouraged to dedicate a portion of his or her time to initiate and develop research projects.

The ideal candidate will have a PhD in a discipline that is directly relevant to bioinformatics. Applicants must have a proven track record and sound understanding of the application of genome technologies and bioinformatics in the context of genomics and genetics, and practical experience with the processing and analysis of large genomic sequencing datasets. Knowledge of high-performance computing, cloud computing and common programming languages used in scientific data analysis, is essential. The ability to communicate effectively in a multi-disciplinary research environment is important. Experience of staff supervision will be advantageous.

For more information on the Imperial BRC Genomics Facility please visit http://www.imperial.ac.uk/genomicsfacility.

Interview date: TBC

Our preferred method of application is online via our website http://www3.imperial.ac.uk/employment (please select “Job Search” then enter the job title or vacancy reference number including spaces into “Keywords”).  Please complete an application form as directed.

Should you have any queries regarding this role please contact:
Professor Jorge Ferrer
jorge.ferrer@imperial.ac.uk

Should you have any queries regarding the recruitment system or application process please contact:
Emma Da Silva
Senior HR Administrator
emma.dasilva@imperial.ac.uk

For technical issues when applying online, please contact: recruitment@imperial.ac.uk

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