Postdoctoral Research Fellow

The University of Edinburgh - Centre for Inflammation Research

A British Heart Foundation (BHF) / Centre for Vascular Regeneration funded Research Fellow position (for 2 years, with a possible 3rd year dependent on progress) is available with Professor Neil Henderson within the MRC Centre for Inflammation Research at the University of Edinburgh.

Ischaemic heart disease is the leading cause of death worldwide, a major challenge is the treatment of patients who develop chronic heart failure after myocardial infarction (MI) due to progressive left ventricular (LV) remodelling. The development of chronic heart failure post-MI is markedly influenced by the initial infarct size and the early tissue repair processes that resolve the necrotic infarct and replace it with a fibrous scar. Mesenchymal cells are the major source of fibrotic extracellular matrix during cardiac repair post-MI.

We aim to identify the key pro-reparative mesenchymal subpopulations driving effective cardiac repair, which will allow the identification of new, rational pro-regenerative targets to treat patients with chronic heart failure post-MI. 

The post holder will use a broad range of cutting-edge techniques including novel transgenic reporter murine models of myocardial infarction, multicolour flow cytometry / cell sorting, and single cell RNA sequencing to identify and characterise the pro-regenerative mesenchymal subpopulations post-MI. Parallel single cell RNA sequencing studies of the cardiac mesenchyme will also be undertaken from human cardiac tissue samples.

The post requires a highly motivated candidate with (or soon to obtain) a PhD, and expertise in in vitro and in vivo basic science techniques.

Closing date: 05 February 2018 at 5pm

For more information and to submit an application, please use the ‘apply’ button below.

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