Research Associate - Congenital Disorders of Glycosilation

Cardiff University - School of Pharmacy and Pharmaceutical Sciences

Applications are invited for a post-doctoral position funded by a biopharmaceutical company to make a leading contribution to the project: Carbohydrate derivatives as substrate replacement therapy for the treatment of Congenital Disorders of Glycosilation' (CDGs). CDGs are a group of inherited disorders affecting glycan biosynthesis and metabolism. These disorders are caused by mutations in genes encoding for specific enzymes responsible for the proper glycosylation of protein.

The successful applicant will join a well-funded and equipped laboratory, carrying out cutting-edge research in phosphorus, nucleosides and carbohydrate chemistry. Specifically, the post holder will conduct research in the area of synthetic sugar phosphate direct to the development of small molecules as substrate replacement therapy in CDGs. The successful candidate will be a highly motivated self-starter who is able to work effectively independently and as part of a team. He/she must have a track record of productivity with strong synthetic chemistry problem solving and analytical skills; excellent scientific expertise in organic synthesis including carbohydrate multi-step synthesis, compound purification, and structural characterization via 1D and 2D multinuclear Nuclear Magnetic Resonance; the ability to design and adapt synthetic routes to obtain target compounds and support structure-activity studies; the ability to champion chemistry efforts from initiation to achieve project milestones; excellent written and verbal communication skills; the ability to maintain excellent documentation of their work.

Highly desirable qualifications include: 1) good publication record; 2) experience with Phosphorus (V) and Phosphorus (III) chemistry, 3) HPLC and LC-MS analysis.

An interest in interdisciplinary research, with willingness to communicate across traditional scientific boundaries is vital as this post involve collaboration with industrial as well as cross- disciplinary partners beyond the core team.

For informal enquiries, please contact Dr. Fabrizio Pertusati at:

This post is full-time, fixed term from 1st March 2018 for 1 year.

Date advert posted: Friday, 5 January 2018

Please be aware that Cardiff University reserves the right to close this vacancy early should sufficient applications be received.

Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds who have the ambition to create a University which seeks to fulfil our social, cultural and economic obligation to Cardiff, Wales, and the world. In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.

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