Postdoctoral Training Fellow in Evolution of Metabolic Networks

The Francis Crick Institute

Contract: Fixed-term, 4 years Full time

Short summary

We seek a talented and motivated scientist at postdoctoral level to join Markus’s Ralser’s laboratory ‘Molecular Biology of Metabolism’ at the Francis Crick Institute. The project is to elaborate the nature of metabolic exchange interactions in eukaryotes, and is attractive for a computational biologist. Ideally, you have a background in Biochemistry, Systems Biology/Functional Genomics, or Microbiology. This is a mostly computational project, in which techniques of data driven biology and/or network modelling are used to understand how metabolic networks operate.

Project scope

Dr Ralser’s laboratory focuses on the understanding of molecular mechanisms that connect the metabolic network to the genome. We address how metabolism influences the formation of metabolic exchange interactions in communities formed of single cellular organisms, how metabolism is regulated, and how the transcriptome and the proteome interact with cellular metabolism. We have, for instance, discovered the importance of the glycolytic/pentose phosphate pathway transition to prevent oxidative stress when cells respire, provide experimental evidence about the evolutionary origins of central metabolism through non-enzymatic chemical reactions, and demonstrated recently that functional metabolomics can elucidate so far missed gene function. The laboratory head Markus Ralser is a mid-career group leader, and attracted several high-profile grants and recognitions for his research in metabolism. These include a membership in the Embo Young Investigator programme, a Wellcome Beit fellowship, an ERC Starting grant, a Wellcome Trust Investigator award, the BioMed Central award and the Colworth medal.  

Details of research projects currently being undertaken can be seen at:

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

The closing date for applications is 08 February 2018 at 23:30.

All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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