Postdoctoral Scientist - Structural Biology

University of Oxford - Nuffield Department of Medicine (NDM)

(2 posts)

Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford

We are seeking two postdoctoral scientists with expertise in protein crystallography and biochemistry to explore new potential drug targets for treatment or prevention of dementia.

The Accelerating Medicines Partnership - Alzheimer's Disease (AMP-AD, is an ambitious project funded by the US National Institute of Health, pharmaceutical companies and non-profit organisations. It integrates data from RNA, protein and metabolomics measurements in brain samples, network analysis and pathway modelling, to identify potential new drug targets and biomarkers for Alzheimer treatment and prevention. In its second phase, a selected set of targets are moved forward to further validation studies. The Gileadi group has extensive experience in structure and chemical biology of novel human proteins, and enjoys access to technologies for structure-guided chemical development for new target classes,

The two postdoctoral scientist roles will each be responsible for a diverse set of novel candidate target genes: In particular, develop methods for expression and purification of the target proteins, structural analysis by crystallography and other methods, biochemical activity assays, and identification of ligands by screening and structure-guided approaches, including the crystallography-based fragment screen (

You will be educated to PhD degree level in structural biology or possess equivalent experience (or be close to completion of a PhD). Proven experience in protein biochemistry and crystallography would be essential. In addition, the ability to plan and perform experiments independently. You will be able to work as part of a multidisciplinary team and be well-organised in planning and documenting experiments.

The two posts are full-time and available on a fixed-term contract until 31 August 2019 in the first instance.

You will be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post.

Only applications received before 12.00 noon on 5 February 2018 will be considered.

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South East England