Clinical Research Associate

UCL Institute of Neurology - Department of Neurodegenerative Disease

Applications are invited for a Clinical Research Associate to join the UCL Huntington’s Disease (HD) Centre at the UCL Institute of Neurology. The post holder will work on the HD-CSF project, an innovative study funded by the MRC and led by Dr Edward Wild, that seeks to further understanding of neurodegeneration by studying cerebrospinal fluid.

This post will primarily support the clinical aims of the HD-CSF study through an innovative Digital Biomarker extension, in which participants will be supplied with smartphone and smartwatch monitoring devices to passively and actively collect clinical data in the participants’ everyday lives. The Digital Biomarker project is a new key collaboration with Roche Pharmaceuticals, who are partnered with Ionis Pharmaceuticals to develop and test novel ‘gene silencing’ or huntingtin-lowering therapies. The post holder may have the opportunity to become involved in this clinical trial programme.

The post holder will be an integral part of the new UCL HD Centre and gain exciting research and clinical experience in neurogenetics, neurodegenerative diseases, Huntington’s disease, clinical assessments, movement disorders, CSF biology, neuroimaging research and early phase molecular therapy clinical trials.  While not linked to a higher degree programme, the post provides an excellent opportunity to obtain research experience under expert supervision, and to generate, analyse and publish data that could form the basis of a Fellowship application or MD/PhD programme.    The post holder will also participate in the multidisciplinary HD and other clinics at the NHNN, both under the clinical supervision of Dr Edward Wild. The award-winning HD clinic cares for patients with HD from premanifest gene carriers through to patients with advanced disease and receives referrals from all over country.    An Honorary Clinical Assistant contract will be sought from UCLH NHS Foundation Trust, for which a DBS check will be required.

Applicants must be Registered Medical Practitioners permitted to practise in the UK, have completed general medical training to SHO/ST2 or equivalent level, and be independently proficient in lumbar puncture.   A very high level of consideration and care for patients and research participants, excellent oral and written communication skills, and the ability to work co-operatively in a multi-disciplinary setting, are essential.  Experience of working in neurology or genetics at ST3 (or equivalent) or above, and an interest in neurodegenerative disease, are desirable.

The post is available immediately, and is funded by a research grant from Roche Pharmaceuticals, for 19 months in the first instance. Starting salary on UCL Grade CL7 in the range £34,962 to £43,522 per annum including London Allowance, superannuable.

You should apply for this post through UCL’s online recruitment website,, where you can download a full job description and person specification using ref 1707049.

If you have any queries regarding the application process, please contact Miss E Bertram, HR Manager, UCL Institute of Neurology (email:

Informal enquiries concerning the post can be made to Dr Edward Wild (

Closing date for applications: 26 January 2018

Interview date: 1 or 2 February 2018

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